IVIS Spectrum Imaging Core

  • Imaging, IVIS, Research, X-RAD

Photograph of the IVIS spectrum Imaging instrument

IVIS Spectrum Imaging Core

无创 体内 imaging allows researchers to sequentially image animals over time yielding valuable information on disease progression, cell trafficking 和 gene expression patterns in living animals.  The RTSF IVIS Spectrum Imaging Core at Michigan State University is a versatile, advanced 体内 500 Internal Server Error

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A time-lapse photo showing Spectrum Imaging


The IVIS Spectrum System provides the following:

  • A light-tight imaging chamber for quantitative bioluminescent 和 fluorescent imaging 体内体外.
  • An integrated gas (isoflurane) anesthesia (XGI-8 anesthesia system), allows for repeated daily use in rodents.
  • A heated stage, to help maintain body temperature during imaging.
  • High throughput, image up to 5 mice at a time.
  • A versatile field of view allows imaging ranging from single cells to 5 whole animals.
  • The Imaging Wizard guides the user through imaging set-up 和 acquisition.
  • Narrowband excitation and emission filters 和 spectral unmixing algorithms allow spectral scanning over blue to near-infrared wavelengths.
  • Multispectral imaging and advanced spectral unmixing algorithms allow visualization of multiple reporters (bioluminescent 和/or fluorescent) in the same animal.
  • An XIC-3 animal isolation chamber provides biological isolation of anesthetized animals during imaging.
  • Living Image 4.0 software allows 3D reconstruction and quantitation of optical signals (number of cells or dye concentration) for both bioluminescent 和 fluorescent sources.
  • Co-registration with the digital "mouse atlas" (or other imaging modalities) provides an anatomical context of reconstructed optical data.

Materials Available to Researchers

  • IVIS cleaning supplies: Sporicidin, MilliQ water, 70% Ethanol
  • 金湿巾
  • Isoflurane (with bottle key adapters)
  • Oxygen tanks for the XGI-8 anesthesia machine 和 LEI Medical table top anesthesia machine
  • Black Artagain paper
  • F-空气罐
  • For the XIC-3 Animal Isolation Chamber: optical lens solution, lint-free optical wipes
  • 杀菌湿巾


  • Adjoining animal room (286 sq. ft.) with Innovive Disposable IVC Caging system.
  • 6 ft. NuAire class II type A2 biosafety cabinet.
  • Lei bench top (isoflurane) anesthesia machine for animal manipulations/procedures prior to imaging with the IVIS Spectrum.
  • Scheduling calendar for room/equipment reservation.
  • Authorized access to the facility.
  • Lab designated login 和 password for the IVIS Spectrum
  • For more information or to tour the facility, contact Dr. S和ra O'Reilly (rtsf.ivis@msu.edu)。


The IVIS Spectrum Imaging Core works on a re-charge system.  Costs can vary depending on whether assistance is required for imaging.

All off-campus customers are subject to a 2% University Administrative Fee.